Home HOME Neoplasma 2011 Neoplasma Vol.58, No.3, p.245-250, 2011

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Neoplasma Vol.58, No.3, p.245-250, 2011

Title: Prediction of survival and cancer recurrence using F-18 FDG PET/CT in patients with surgically resected early stage (Stage I and II) non-small cell lung cancer
Author: Y. S. KIM, S. J. KIM, Y. K. KIM, I. J. KIM, Y. D. KIM, M. K. LEE

Abstract: The aim of the current study was to investigate the prognostic value of SUVmax in patients with completely resected early stage (stage I and II) NSCLC.
A retrospective review identified 76 patients with surgically resected early (stage I and II) NSCLC who received F-18 FDG PET/CT at diagnosis of cancer. Survival analysis was conducted using Kaplan-Meier analysis, and survival curves stratified by age, sex, mediastinal lymph node involvement, SUVmax, and TNM staging were generated for estimation of overall survival and disease free survival (DFS). Independent predictive factors for survival were determined using Cox proportional hazard model.
For overall survival, the median survival of the patients with tumor SUVmax≤6.7 was 48.9 months and was significantly longer than the patients with tumor SUVmax>6.7 (Log rank test, Χ2=18.01, p5.9. The median survival of the patients with tumor SUVmax≤5.9 was 31.7 months (Log rank test, Χ2=16, p=0.0001).
In conclusion, high FDG uptake measured by F-18 FDG PET/CT might have a prognostic value for overall survival and DFS in surgically resected early stage (stage I and II) NSCLC even after stratified by pathologic stages. 

Keywords: F-18 FDG, Early stage, non-small cell lung cancer, overall survival, disease free survival
Year: 2011, Volume: 58, Issue: 3 Page From: 245, Page To: 250
doi:10.4149/neo_2011_03_245
Price: 14.40 €






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