Home Acta Virologica 2011 Acta Virologica Vol.55, No.1, p.23-29, 2011

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.55, No.1, p.23-29, 2011

Title: Selenium deficiency contributes to the chronic myocarditis in coxsackievirus-infected mice
Author: E. J. JUN, J. S. YE, I. S. HWANG, Y. K. KIM, H. LEE

Abstract:  Both coxsackievirus B3 (CVB3) infection and selenium (Se) deficiency play a pivotal role in Keshan disease of the heart. The Se deficiency was known to contribute to the CVB3-induced myocarditis in acute and subacute phase of infection. However, its effect on the myocarditis in chronic phase of infection has not been examined yet. To address this question, we kept mice on a Se-replete or Se-deficient diet for 28 days, infected them intraperitoneally with CVB3 and maintaining previous diets, we examined them for next 90 days for several parameters indicative of the infection or disease. We found out that the mice on the Se-deficient diet exhibited a higher mortality, lower serum glutathione peroxidase (GPx) activity, evident histopathological changes indicative of myocarditis, and a higher level of viral RNA in the heart. Summing up, these data suggest that the Se-deficiency creates a chronic myocarditis-prone condition by fostering the active virus replication.

Keywords: coxsackievirus B3; mice; selenium deficiency; myocarditis; glutathione peroxidase; viral RNA
Year: 2011, Volume: 55, Issue: 1 Page From: 23, Page To: 29
doi:10.4149/av_2011_01_23


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