Home Acta Virologica 2011 Acta Virologica Vol.55, No.1, p.75-79, 2011

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.55, No.1, p.75-79, 2011

Title: Small interfering RNAs inhibit infectious bursal disease virus replication in Vero cells
Author: B. K. SAJJANAR, A. MISHRA, A. SONAWANE, C. L. PATEL, A. SAXENA, B. B. DASH, A. RAI, A. A. RAUT

Abstract:  Small interfering RNA (siRNA) molecules are considered to be a promising antiviral therapeutics. This study was performed to analyze the application of siRNA against infectious bursal disease virus (IBDV) replication. Two siRNAs were designed to target common coding sequences of four IBDV proteins. Corresponding vectors were constructed to express anti-IBDV short hairpin RNAs (shRNA) that were tested for their antiviral effect in Vero cells. The results showed that expressed shRNA inhibited the virus replication to a significant extent (92%) as determined by the virus titration in cell culture. This outcome demonstrated the effectiveness of RNA interference (RNAi) based mechanism against the IBDV in vitro.

Keywords: infectious bursal disease virus; RNA interference
Year: 2011, Volume: 55, Issue: 1 Page From: 75, Page To: 79
doi:10.4149/av_2011_01_75


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