Home Neoplasma 2011 Neoplasma Vol.58, No.4, p.320-325, 2011

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Neoplasma Vol.58, No.4, p.320-325, 2011

Title: Effect of justicidin B – a potent cytotoxic and pro-apoptotic arylnaphtalene lignan on human breast cancer-derived cell lines
Author: G. MOMEKOV, S. KONSTANTINOV, I. DINEVA, I. IONKOVA

Abstract: Justicidin B produced by genetically transformed cultures of Linum leonii was tested for cytotoxic activity and induction of apoptosis in MDA-MB-231 and MCF-7 breast cancer derived cell lines. The tested lignan evoked strong, concentration dependent cytotoxicity in both cell lines, whereby MCF-7 proved to be far more sensitive as compared to MDA-MB-231. The 24 h treatment of both cell lines increased the level of apoptotic DNA fragmentation; however the proapoptotic activity is completely inhibited if the cells are co-incubated with the non-selective pan-caspase inhibitor Boc-Asp(OMe)-fluoromethyl ketone (PCI), which implies that justicidin B, activates programmed cell death via caspase –dependent mechanisms. Exposure of MDA-MB-231 cells with justicidin B leads to concentration dependent decrease in the expression of NFkB; whereas the treatment of MCF-7, is consistent with strong increase in the expression of this transcription factor.

Keywords: Justicidin B, cytotoxicity, apoptosis, NFkB, MCF-7, MDA-MB-231
Year: 2011, Volume: 58, Issue: 4 Page From: 320, Page To: 325
doi:10.4149/neo_2011_04_320
Price: 14.40 €






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