Home Neoplasma 2011 Neoplasma Vol.58, No.4, p.343-347, 2011

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.58, No.4, p.343-347, 2011

Title: Gamma-secretase inhibitor, a potential target therapy for MUC2-positive colorectal carcinoma
Author: X. BU, N. LI, X. TIAN, P. HUANG

Abstract: Notch signaling may be mechanistically involved the colorectal carcinogenesis. Blocking of Notch signaling by gamma-secretase inhibitor may constitute a novel molecular therapy for cancer. In the present study, we blocked the Notch signaling by DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester, a gamma-secretase inhibitor) and investigated the effects on the proliferative and invasive potential of human colorectal cancer LS174T cells, a goblet cell-like colorectal cancer cell line which produces high-levels of MUC2 continuously. DAPT inhibited the proliferation and invasion of LS174T cells. Blocking of Notch signaling by DAPT could down-regulate its downstream target gene Hes1, while enhancing the expression of Math1and MUC2 in LS174T cells. In conclusion, we demonstrated that blocking of Notch signaling by DAPT could inhibit the proliferation and invasion of human colorectal cancer LS174T cells and suggested that gamma-secretase inhibitors may provide a targeted therapy for MUC2-positive colorectal tumors.

Keywords: cancer, colorectum, invasion, proliferation, Notch signaling
Year: 2011, Volume: 58, Issue: 4 Page From: 343, Page To: 347
doi:10.4149/neo_2011_04_343
Price: 12.00 €






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