Home FOR AUTHORS General Physiology and Biophysics 2011 General Physiology and Biophysics Vol.30, No.2, p.207–213, 2011

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Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.30, No.2, p.207–213, 2011

Title: Red wine polyphenols correct vascular function injured by chronic carbon tetrachloride intoxication
Author: Soňa Čačányiová, Oľga Pecháňová, Pavel Babá, Andrea Černá, Pavol Janega, Ramaroson Andriantsitohaina

Abstract:  The aim of the study was to evaluate the effect of red wine polyphenols extract ProvinolsTM on the development of cardiovascular injury in the model of carbon tetrachloride (CCl4) intoxication. We followed the thoracic aorta vasoactivity and left ventricle nitric oxide (NO) synthase activity in male Wistar rats. In the preventive experiment lasting for 12 weeks the control group, the group receiving CCl4 (0.5 ml/kg) two times a week subcutaneously, the group receiving ProvinolsTM (30 mg/kg/day) in drinking water and the group receiving CCl4+ProvinolsTM was used. In the recovery experiment, the initial 12 weeks of CCl4 treatment were followed by 3 weeks of spontaneous recovery or recovery with ProvinolsTM. CCl4-intoxication resulted in the injury of vasoactivity which was demonstrated by the inhibition of acetylcholine-induced relaxation as well as noradrenaline-induced contraction. In the preventive as well as recovery experiment administration of polyphenols refreshed endothelium-dependent relaxant response and normalized inhibited contraction to adrenergic stimuli. ProvinolsTM treatment significantly increased NO-synthase activity in all groups. The results revealed beneficial effects of red wine polyphenols on vascular function injured by chronic CCl4 intoxication. The correction of endothelial function seems to be attributed to the activation of NO pathway by polyphenols.

Keywords: Red wine polyphenols — Carbon tetrachloride — Rat aorta — Vasoactivity — NO-synthase
Year: 2011, Volume: 30, Issue: 2 Page From: 207, Page To: 213

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