Home Acta Virologica 2011 Acta Virologica Vol.55, No.2, p.117-121, 2011

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.55, No.2, p.117-121, 2011

Title: T7 phage displaying latent membrane protein 1 of Epstein-Barr virus elicits humoral and cellular immune responses in rats
Author: J. GAO, Z. LIU, M. HUANG, X. LI, Z. WANG

Abstract:  The latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus (EBV) has become a potential target in EBV-associated tumor prevention and treatment due to its multiple biological effects. In this study, the recombinant T7 phage displaying full-length LMP1 protein was cloned and used as an immunogen to immunize rats. Results of flow cytometry, Western blot analysis, and ELISA confirmed that both humoral and cellular immune responses were elicited in the immunized rats. Our data suggested that T7 phage was an efficient antigen carrier. The recombinant T7-LMP1 phage reconstitutes the antigenic and immunogenic properties of LMP1 and can serve as a vaccine against EBV.

Keywords: Epstein-Barr virus; latent membrane protein 1; T7 phage; phage display; recombinant phage
Year: 2011, Volume: 55, Issue: 2 Page From: 117, Page To: 121
doi:10.4149/av_2011_02_117
Price: 10.00 €






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