Home Acta Virologica 2011 Acta Virologica Vol.55, No.2, p.139-146, 2011

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.55, No.2, p.139-146, 2011

Title: Immunogenicity of the envelope GP3 protein of porcine reproductive and respiratory syndrome virus displayed on baculovirus
Author: Z. S. WANG, X. G. XU, H. J. LIU, Z. C. LI, L. DING, G. S. YU, D. W. TONG

Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) has been recognized as one of the most important pathogens of pigs throughout the world. The minor envelope protein GP3 of PRRSV plays an important role in clearing of the virus infection and protecting the animals. In this study, a recombinant baculovirus (BacSC-GP3) expressing His6-tagged GP3 with the transmembrane (TM) and cytoplasmic (CT) domains of envelope protein gp64 was constructed and its immunogenicity was evaluated in mouse and piglet models. The His6-tagged GP3 was successfully displayed on the surface of virions as well as virus-infected Sf-9 cells. The animals immunized with BacSC-GP3 gave a slightly higher (piglets) up to a markedly higher (mice) humoral and lymphocyte proliferation responses than those that received a commercial killed vaccine. This is the first study on the immunogenicity of recombinant GP3-baculovirus, which indicates that the latter can represent an alternative strategy for developing a more effective PRRSV vaccine.

Keywords: baculovirus; GP3 protein; porcine reproductive and respiratory syndrome virus
Year: 2011, Volume: 55, Issue: 2 Page From: 139, Page To: 146
doi:10.4149/av_2011_02_139
Price: 16.00 €






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