Home HOME Neoplasma 2011 Neoplasma Vol.58, No.5, p.377-385, 2011

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.58, No.5, p.377-385, 2011

Title: Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients
Author: J. HALAMKOVA, I. KISS, Z. PAVLOVSKY, J. TOMASEK, J. JARKOVSKY, Z. CECH, S. TUCEK, L. HANAKOVA, M. MOULIS, J. ZAVRELOVA, M. MAN, P. BENDA, O. ROBEK, Z. KALA, M. PENKA

Abstract: Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI 1, PAI 2, PAI 3 and protease nexin) forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing to the invasive growth and angiogenesis of malignant tumours. In our project we examined the expression of uPA, uPAR, PAI 1 and PAI 2 in tumor tissue and we also studied the plasma levels of PAI 1 before and after the initiation of therapy in patients with colorectal carcinoma in relationship to grade of tumor and the treatment response. In our prospective evaluation we included 80 patients treated for adenocarcinoma of the colon and rectum. Analysis of collected data revealed statistically significant evidence of a relationship between the level of PAI 1 in plasma before treatment and grade of the tumor, which increases with tumor grade (p=0.025). We demonstrated that there exists a statistically significant relationship between the expression of PAI 2 (p

Keywords: colorectal cancer, plasminogen activator system, grade, treatment response
Year: 2011, Volume: 58, Issue: 5 Page From: 377, Page To: 385
doi:10.4149/neo_2011_05_377
Price: 21.60 €






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