Home Endocrine Regulations 2011 Endocrine Regulations Vol.45, No.3, p.131-137, 2011

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Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

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Endocrine Regulations Vol.45, No.3, p.131-137, 2011

Title: 7-hydroxylated derivatives of dehydroepiandrosterone as possibly related to menstrual mood change in healthy women
Author: M. Duskova, K. Simunkova, M. Hill, L. Starka

Abstract: Objective. Mood changes occur often in the luteal phase of menstrual cycle. Steroids modulating GABAA and NAMD receptors in the brain, namely allopregnanolone, were suggested as a factor of premenstrual syndrome. Another neurosteroid influencing the well-being is dehydroepiandrosterone. In the past decade it was shown by several authors that some dehydroepiandrosterone derivatives, especially those with 7-hydroxy- or 7-oxo group, exert a higher activity than dehydroepiandrosterone itself. It was also reasonable to see whether the levels of circulating 7-hydroxy-derivatives of dehydroepiandrosterone differ in the follicular and luteal phase of the menstrual cycle.
Methods. Steroids known to exert neuroprotective effects, namely 7α- and 7β-hydroxy-dehydroepiandrosterone, 5-androstene-3β,7α,17β-triol and 5-androstene-3β,7β,17β-triol, were determined in midfollicular and midluteal phase of the menstrual cycle of 22 healthy women with a regular menstruation cycle.
Results. Whereas the maternal steroids, dehydroepiandrosterone and androstene-3β,17β-diol showed no significant difference between the phases of menstrual cycle, the levels of their 7-hydroxylated metabolites were significantly lower in the luteal phase.
Conclusion. It is suggested that the observed decrease of 7-hydroxylated metabolites during the luteal phase may be a factor related to the etiopathogenesis of mood change and neurocognitive disturbances, which are known to be more accented in that particular phase of the menstrual cycle.

Keywords: menstrual cycle, menstrual mood change, mealthy women, mehydroepiandrosterone, 7-hydroxydehydroepiandrosterone
Year: 2011, Volume: 45, Issue: 3 Page From: 131, Page To: 137
Price: 14.00 €

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