Home General Physiology and Biophysics 2011 General Physiology and Biophysics Vol.30, No.3, p.239–250, 2011

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.30, No.3, p.239–250, 2011

Title: Investigation of ABC transporter from mycobacterial arabinogalactan biosynthetic cluster
Author: Petronela Dianišková, Jana Korduláková, Henrieta Škovierová, Devinder Kaur, Mary Jackson, Patrick J. Brennan, Katarína Mikušová

Abstract: Two genes from the “mycobacterial arabinogalactan biosynthetic cluster” spanning the region from Rv3779 to Rv3809c in the genome of Mycobacterium tuberculosis H37Rv were annotated as possible components of the ATP-binding cassette transporter. Rv3781 encodes a nucleotide-binding domain and Rv3783 determines production of a membrane-spanning domain. We have examined possible roles of these genes in mycobacterial cell wall biosynthesis through inactivation of their respective orthologs in Mycobacterium smegmatis mc2155, phenotypic characterization of the mutant strains via metabolic labeling with [U-14C]-glucose, cell-free reactions with UDP-[U-14C]-galactose monitoring galactan build-up and transcriptional analysis. Several lines of evidence suggest that this ABC transporter is involved in biosynthesis of arabinogalactan, although more investigation is needed to establish its precise role or the transported substrate.

Keywords: Mycobacterium — Cell wall — ABC transporter
Year: 2011, Volume: 30, Issue: 3 Page From: 239, Page To: 250

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