Home General Physiology and Biophysics 2011 General Physiology and Biophysics Vol.30, No.3, p.271–277, 2011

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.30, No.3, p.271–277, 2011

Title: Interaction between sympathetic nervous system and renin angiotensin system on MMPs expression in juvenile rat aorta
Author: Houcine Dab, Rafik Hachani, Wassim Hodroj, Mohsen Sakly, Giampiero Bricca, Kamel Kacem

Abstract: The aim of our present study is to investigate the interaction between angiotensin II (ANG II) and sympathetic nervous system (SNS) on matrix metalloproteinase MMP-2 and MMP-9 expression and activity in juvenile rat aorta under normal conditions. Sympathectomy with guanethidine and blockade of the ANG II receptors (AT1R) by losartan were performed alone or in combination on new-born rats. mRNA, protein expression and activity of MMP-2 and MMP-9 were examined by Q-RT-PCR, immunoblotting and zymography, respectively.
MMP-2 mRNA and protein amount were decreased after sympathectomy or AT1R blockade and an additive effect was observed after combined treatment. However, MMP-9 expression was reduced to the same level in the three treated groups. There were some detectable gelatinolytic activity of the MMPs in both control and treated rats.
We concluded that ANG II stimulates directly and indirectly (via sympathostimulator pathway) the MMP-2 expression but seems unable to affect MMP-9 expression through direct pathway. Combined inhibition of SNS and ANG II were more efficient than a single inhibition in reducing MMP amounts in rat vessels.

Keywords: Sympathectomy — Angiotensin II — AT1R antagonist — MMP-2 — MMP-9 — Aorta
Year: 2011, Volume: 30, Issue: 3 Page From: 271, Page To: 277

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