Home General Physiology and Biophysics 2011 General Physiology and Biophysics Vol.30, No.3, p.321–324, 2011

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Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.30, No.3, p.321–324, 2011

Title: The effect of chronic food restriction on immunopositive ACTH cells in peripubertal female rats
Author: Verica Lj. Milošević, Vladimir Z. Ajdžanović, Desanka B. Bogojević, Ivana M. Medigović, Svetlana K. Ivanović-Matić, Vesna I. Martinović, Ilijana I. Grigorov


In peripubertal female rats, we have previously found that 50% food restriction (FR) increases plasma IL-6, haptoglobin and both alanine transaminase (ALT) and alkaline phosphatase (AST) aminotransferases, indicating the existence of an inflammatory response. To study whether such FR influences the hypothalamic-pituitary-adrenal (HPA) axis, we examined by immunohistochemistry the morphofunctional features of pituitary adrenocorticotropic (ACTH) cells.

In FR rats the volume and volume density of ACTH cells as well as plasma ACTH levels were increased by 17.6%, 12.5% and 13.4%, respectively, in comparison with controls (p < 0.05). We concluded that chronic FR is a systemic stressor in young females, capable to stimulate the HPA axis, probably as a result of IL-6 action.

Keywords: Food restriction — Female rats — ACTH cells — ACTH
Year: 2011, Volume: 30, Issue: 3 Page From: 321, Page To: 324

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