Home Acta Virologica 2011 Acta Virologica Vol.55, No.3, p.189-194, 2011

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Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.55, No.3, p.189-194, 2011

Title: Heat-shock protein 70 is associated with the entry of Marek΄s disease virus into fibroblast
Author: XIAO-JIA WANG

Abstract: Literature pertaining to the interactions between Marek΄s disease virus (MDV) entry-related glycoproteins and corresponding receptors is still limited. Results from a Western blot analysis of cellular proteins for virus receptors and co-immunoprecipitation suggest that heat shock protein 70 (HSP70) is a potential cellular receptor for MDV glycoprotein gH. Plaque inhibition assays confirm the involvement of HSP70 in the early stages of MDV entry into chicken embryo fibroblasts (CEF). The present work supports that HSP70 is implicated in the MDV entry process by binding to gH, and enhances the understanding of multifunctional HSP70 and the MDV infection process.

Keywords: Marek΄s disease virus (MDV); heat shock protein 70 (HSP70); glycoprotein H; virus entr
Year: 2011, Volume: 55, Issue: 3 Page From: 189, Page To: 194
doi:10.4149/av_2011_03_189
Price: 12.00 €






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