Home Acta Virologica 2011 Acta Virologica Vol.55, No.3, p.203-217, 2011

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.55, No.3, p.203-217, 2011

Title: Horizontal gene transfer in herpesviruses identified by using support vector machine
Author: M. FU, R. DENG, J. WANG, X. WANG

Abstract: Horizontal gene transfer (HGT) is the probable origin of new genes. Identification of HGT-introduced genes would be helpful to the understanding of the genome evolution and the function prediction of new genes. In this study, a method using support vector machine (SVM) was used to distinguish horizontally transferred genes and non-horizontally transferred genes of mammalian herpesviruses based on the atypical composition identification, with accuracy higher than 95% within a reasonable length of time by using just a common PC. This identified 302 putative horizontally transferred genes, 171 genes being identified for the first time. Although most putative transferred genes are of unknown function, many genes have been discovered or predicted to encode glycoproteins or membrane proteins.

Keywords: horizontal gene transfer; identification; herpesvirus
Year: 2011, Volume: 55, Issue: 3 Page From: 203, Page To: 217
doi:10.4149/av_2011_03_203
Price: 30.00 €






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