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Neoplasma Vol.59, No.1, p.6-17, 2012
|Title: Differentiation pathways in carcinogenesis and in chemo- and radioresistance|
|Author: M. Janikova, J. Skarda|
|Abstract: Cancer stem cells (CSCs) share many features with embryonic stem cells (ESCs) such as the ability for self-renewal and differentiation. Signaling pathways that are involved in these processes are also involved in chemo- and radioresistance (e.g. Wnt, Notch and Hedgehog pathways). This review is focused on the influence of three important differentiation pathways on carcinogenesis and on chemo- and radioresistance in ESCs and CSCs.
|Keywords: Stem cell, Chemoresistance, Radioresistance, Wnt pathway, Notch pathway, Hedgehog pathway|
|Received: 18-Mar-2011||Published online: 20-Oct-2011|
|Year: 2012, Volume: 59, Issue: 1||Page From: 6, Page To: 17|