Home Neoplasma 2012 Neoplasma Vol.59, No.1, p.6-17, 2012

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.59, No.1, p.6-17, 2012

Title: Differentiation pathways in carcinogenesis and in chemo- and radioresistance
Author: M. Janikova, J. Skarda

Abstract: Cancer stem cells (CSCs) share many features with embryonic stem cells (ESCs) such as the ability for self-renewal and differentiation. Signaling pathways that are involved in these processes are also involved in chemo- and radioresistance (e.g. Wnt, Notch and Hedgehog pathways). This review is focused on the influence of three important differentiation pathways on carcinogenesis and on chemo- and radioresistance in ESCs and CSCs.

Keywords: Stem cell, Chemoresistance, Radioresistance, Wnt pathway, Notch pathway, Hedgehog pathway
Received: 18-Mar-2011 Published online: 20-Oct-2011
Year: 2012, Volume: 59, Issue: 1 Page From: 6, Page To: 17

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