Home 
General Physiology and Biophysics 2011 General Physiology and Biophysics Vol.30, No.4, p.350–355, 2011
General Physiology and Biophysics 2011 General Physiology and Biophysics Vol.30, No.4, p.350–355, 2011
Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2011 Special Issue 2010 2009 2008 2007 Neoplasma Acta Virologica Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
General Physiology and Biophysics Vol.30, No.4, p.350–355, 2011 |
||
| Title: Nicotine reduces mortality of developing rats exposed to high-altitude hypoxia and partially suppresses the duration of cortical epileptic afterdischarges | ||
| Author: Vladimír Riljak, Dana Marešová, Jaroslav Pokorný | ||
| Abstract: Nicotine has been repeatedly reported as substance possessing neuroprotective properties. This study focused on the possible beneficial effects of nicotine against the high-altitude hypoxia (9000 m for one hour). 15 min prior to hypoxia exposition rats (12- and 35-day-old) were treated with nicotine. Next day electrodes have been implanted and the effects of nicotine and hypoxia (or both factors) on duration of afterdischarges (Ads) were tested. Administration of nicotine declined the hypoxia-induced mortality in 35-day-old animals. Nicotine pretreatment had no effect on ADs duration in 12-day-old pups, therefore brought about suppression of ADs in 35-day-old animals. Taken together, our data show that nicotine exhibits an anticonvulsant effect that is age-dependent. The mechanisms of nicotine neuroprotective properties include probably the influence of calcium homeostasis, increase synthesis of variety of growth factors, inhibition of the caspase cascades and antioxidant capability of nicotine. |
||
| Keywords: Brain cortex — Afterdischarges — Hypoxia — Nicotine | ||
| Year: 2011, Volume: 30, Issue: 4 | Page From: 350, Page To: 355 | |
| doi:10.4149/gpb_2011_04_350 |
||
|
|
 download file |
|
|
2011 Special Issue |