General Physiology and Biophysics Vol.30, No.4, p.403

General Physiology and Biophysics Vol.30, No.4, p.403–409, 2011

Founded: 1982
ISSN 1338-4325 (online)
ISSN 0231-5882 (print)
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General Physiology and Biophysics Vol.30, No.4, p.403–409, 2011
Title: T-type calcium channel blockers – new and notable
Author: Ľubica Lacinová

Abstract: Since cloning of the T-type or CaV3.n calcium channel family in 1998–1999 much progress was made in investigation of their regulation. Most effective metal CaV3 channel blockers are trivalent cations from lanthanide group together with transition metals La3+ and Y3+. Divalent cations Zn2+, Cu2+ and Ni2+ inhibit CaV3.2 channels more efficiently than CaV3.1 and CaV3.3 channels via second high-affinity binding site including histidine H191 specific for the CaV3.2 channel. Dihydropyridines and phenylalkylamines in addition to block of L-type calcium channel can inhibit CaV3 channels in clinically relevant concentration.

Keywords: T-type calcium channels — Dihydropyridines — Phenylakylamines — Zn2+, Cu2+, Ni2+, Co2+, Cd2+, La3+, Er3+, Y3+

Year: 2011, Volume: 30, Issue: 4	Page From: 403, Page To: 409
doi:10.4149/gpb_2011_04_403
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