Home HOME Acta Virologica 2011 Acta Virologica Vol.55, No.4, p.289-294, 2011

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Quarterly, 72-88 pp. per issue
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.55, No.4, p.289-294, 2011

Title: An oral Sindbis virus replicon-based DNA vaccine containing VP2 gene of canine parvovirus delivered by Escherichia coli elicits immune responses in dogs
Author: S. S. DAHIYA, M. SAINI, P. KUMAR, P. K. GUPTA

Abstract: A Sindbis virus replicon-based DNA vaccine containing VP2 gene of canine parvovirus (CPV) was delivered by Escherichia coli to elicit immune responses. The orally immunized dogs developed CPV-specific serum IgG and virus neutralizing antibody responses. The cellular immune responses analyzed using lymphocyte proliferation test and flow cytometry indicated CPV-specific sensitization of both CD3+CD4+ and CD3+CD8+ lymphocytes. This study demonstrated that the oral CPV DNA vaccine delivered by E. coli can be considered as a promising approach for vaccination of dogs against CPV.

Keywords: canine parvovirus; DNA vaccine; VP2; Sindbis virus replicon; E. coli
Year: 2011, Volume: 55, Issue: 4 Page From: 289, Page To: 294
doi:10.4149/av_2011_04_289


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