Acta Virologica Vol.55, No.4, p.303-310, 2011

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Founded: 1957
ISSN 0001-723X
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Acta Virologica Vol.55, No.4, p.303-310, 2011
Title: Characterization of a new dog isolate of canine distemper virus from China
Author: J. QIAO, Q. MENG, C. CHEN, X. XIA, X. CAI, Y. REN , H. ZHANG

Abstract: Canine distemper virus (CDV) is a highly contagious pathogen of dogs. Vaccination is an effective way to protect dogs from CDV infection, but occasionally fails. In the present study, a wild type (wt) CDV, named XJ2, was isolated from a dead vaccinated dog. The hemagglutinin (H) gene of the XJ2 was amplified and analyzed for the molecular characteristics including N-glycosylation sites, phylogenesis, hydrophobicity and epitopes. The data indicated that XJ2 was a genetic variant strain of CDV. CDV-sero-negative dogs were inoculated intranasally with XJ2, developed severe clinical symptoms and died, suggesting high virulence.

Keywords: canine distemper virus; hemagglutinin gene; virulence; Chinese isolate; dogs

Year: 2011, Volume: 55, Issue: 4	Page From: 303, Page To: 310
doi:10.4149/av_2011_04_303
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