Acta Virologica Vol.55, No.4, p.311-316, 2011

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ISSN 0001-723X
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Acta Virologica Vol.55, No.4, p.311-316, 2011
Title: Effect of Rta protein of Epstein-Barr virus on the cell cycle in HeLa cells
Author: QINGWEI GUO, XIAOBAI SUN, CHANGJIN YUAN, HUIJUAN ZHOU, YANMEI LI, GAO JIE, GUOSHENG JIANG

Abstract: Epstein-Barr virus (EBV) replication and transcription activator (Rta) is an immediate-early transcription factor that mediates the switch from latent to lytic infection. DNA viruses often modulate the function of critical cell cycle proteins to maximize the efficiency of virus replication. Here we have examined the effect of Rta on cell cycle progression. Cell cycle analysis revealed that Rta induced HeLa cells in G0/G1-phase to reenter the S-phase. Analysis of the expression pattern of a key set of cell cycle regulators revealed that expression of Rta inhibited the expression of Rb and p53 and induced the expression of E2F1. These findings suggest that Rta plays an active role in redirecting HeLa cell physiology through an Rta-mediated cell cycle transformation.

Keywords: Epstein-Barr virus; Rta; Rb; p53; E2F-1; cell cycle; HeLa cells

Year: 2011, Volume: 55, Issue: 4	Page From: 311, Page To: 316
doi:10.4149/av_2011_04_311
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