Home 
CONTACT Acta Virologica 2011 Acta Virologica Vol.55, No.4, p.349-352, 2011
CONTACT Acta Virologica 2011 Acta Virologica Vol.55, No.4, p.349-352, 2011
Journal info
|
||
Select Journal
Journals
Bratislava Medical Journal Endocrine Regulations General Physiology and Biophysics Neoplasma Acta Virologica Current articles 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Studia Psychologica Cardiology Letters Psychológia a patopsych. dieťaťa Kovove Materialy-Metallic Materials Slovenská hudbaWebshop Cart
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Acta Virologica Vol.55, No.4, p.349-352, 2011 |
||
| Title: Genetic characterization of vaccine and field strains of serotype A foot-and-mouth disease virus from India | ||
| Author: J. K. MOHAPATRA, S. S. PAWAR, C. TOSH, S. SUBRAMANIAM, R. PALSAMY, A. SANYAL, D. HEMADRI, B. PATTNAIK | ||
| Abstract: Extreme antigenic and genetic heterogeneity of serotype A foot-and-mouth disease virus (FMDV) population has resulted in change of vaccine strains in India twice in the last decade. In such a situation, complete characterization of the vaccine strains is imperative. With regard to the frequent outbreaks of this disease, FMDV field strains are also of interest. Therefore three vaccine strains and two field strains of type A FMDV from India were completely sequenced and the obtained sequences were subjected to sequence and phylogenetic analyses. Based on the complete coding region, all the Indian strains clustered in the Asia topotype and exhibited a more than 11% nt divergence from the other Asian strains. The 5’-UTR of some Indian strains revealed block deletions of 43 and 86 nt corresponding to the pseudoknot region. Amino acids S44 in VP2 and F164 in VP1 were found to be the exclusive signatures for the Asia topotype. The vaccine strains differed at 65 aa positions in the capsid region, 13 of them antigenically critical. Variability at such positions is likely to affect the antigenic profile of these strains. Complete genome sequences of the vaccine strains presented here could serve as the reference for any comparative genomics in future. |
||
| Keywords: foot-and-mouth disease virus; vaccine strains; field strains; India | ||
| Year: 2011, Volume: 55, Issue: 4 | Page From: 349, Page To: 352 | |
| doi:10.4149/av_2011_04_349 |
||
|
|
 download file |
|