Home General Physiology and Biophysics 2012 General Physiology and Biophysics Vol.31, No.1, p.47–55, 2012

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.31, No.1, p.47–55, 2012

Title: Quercetin and epigallocatechin gallate effects on the cell membranes biophysical properties correlate with their antioxidant potential
Author: Denisa Margina, Mihaela Ilie, Gina Manda, Ionela Neagoe, Magdalena Mocanu, Diana Ionescu, Daniela Gradinaru, Constanţa Ganea

Abstract: Quercetin and epigallocatechin gallate are two of the most abundant polyphenols in dietary plants, including apples, onions, red wine and green tea. The bioactivity of polyphenols is linked to their ability to interact with cell membranes without being internalized. The aim of the present study was to assess the short-time effect of these polyphenols on membrane anisotropy and transmembrane potential of U937 monocytes and Jurkat T lymphoblasts. Results showed that quercetin and epigallocatechin gallate induced, after 20 minutes cell exposure, a dose-dependent increase of membrane anisotropy and polarization. Anisotropy increase was correlated with the reduction of lipid peroxidation. Our results could indicate that the antioxidant capacity of the tested polyphenols is due to their stabilizing effect on the cell membranes, thus contributing to cell protection in various pathologies and as adjuvant therapy in highly toxic treatment regimens.

Keywords: Polyphenols — Membrane potential — Membrane anisotropy — Antioxidant potential
Published online: 01-Feb-2012
Year: 2012, Volume: 31, Issue: 1 Page From: 47, Page To: 55

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