Home General Physiology and Biophysics 2012 General Physiology and Biophysics Vol.31, No.1, p.57–64, 2012

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.31, No.1, p.57–64, 2012

Title: Free-radical degradation of high-molar-mass hyaluronan induced by ascorbate plus cupric ions: Testing of stobadine and its two derivatives in function as antioxidants
Author: Lubica Surovcikova-Machova, Katarina Valachova, Maria Banasova, Vladimir Snirc, Elena Priesolova, Milan Nagy, Ivo Juranek, Ladislav Soltes

Abstract: Stobadine·2HCl and its two hydrophilic derivatives SM1dM9dM10·2HCl and SME1i-ProC2·HCl were tested in the function of antioxidants on hyaluronan (HA) degradation induced by the Weissberger oxidative system [ascorbate plus Cu(II)]. As a primary method, rotational viscometry was applied, where the substance tested was added before or 1 h after the initiation of HA degradation. The most effective scavengers of •OH and peroxy-type radicals were recorded to be stobadine·2HCl and SME1i-ProC2·HCl, respectively. The most effective scavenger, determined by applying the ABTS assay, was stobadine·2HCl.

Keywords: ABTS assay — Glycosaminoglycans — Hexahydropyridoindole derivatives — Rotational viscometry — Weissberger oxidative system
Published online: 01-Feb-2012
Year: 2012, Volume: 31, Issue: 1 Page From: 57, Page To: 64

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