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Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.1, p.14-18, 2012
Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.1, p.14-18, 2012
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Bratislava Medical Journal Vol.113, No.1, p.14-18, 2012 |
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| Title: Association of angiotensin converting enzyme gene (I/D) polymorphism with hypertension and type 2 diabetes | ||
| Author: W. A. Zarouk, I. R. Hussein, N. N. Esmaeil, H. M. Raslan, H. A. A. Reheim, O. Moguib, N. A. Emara, A. A. Aly, M. Hamed | ||
| Abstract: Objectives: This study was conducted to determine the association of insertion/deletion (I/D) polymorphism of the ACE gene in hypertensive and T2DM subjects in Egyptian population. Background: The deletion (D) allele of the angiotensin-converting enzyme (ACE) gene has been studied in relation to hypertension and type 2 diabetes mellitus (T2DM) with contradictory results which might be due to ethnic and geographical variations. Methods: A total of 85 subjects participated in this study; hypertension (Group 1); type 2 diabetes mellitus (Group 2) and controls (Group 3). Written informed consent was obtained. for each subject: age, sex, diabetes duration and the drugs used, blood pressure (systolic and diastolic), and lipid profile. Genotyping was performed by polymerase chain reaction (PCR). Results: The frequency of DD genotype was significantly higher in hypertensive (60 %) and diabetic patients (68 %) compared to controls (33.3 %) (p=0.04, p=0.01 respectively). The DD genotype (vs DI and II genotype) in the hypertensive and diabetic groups is associated with increased risk of hypertension and/or diabetes. OR=3.00; 95%, Cl = 0.993–9.067; OR=4.250; 95%, Cl = 1.234–14.63 respectively). The D allele was more frequent in hypertensive (77.5 %) and diabetic patients (82 %) compared to controls (52.4 %) (p=0.004 and 0.002 respectively). The D allele (vs the I allele) is associated with increased risk of hypertension and diabetes OR=3.13, 95%Cl=1.405–6.978; OR= 4.14, 95% CI= 1.615–10.622 respectively). Conclusion: The DD genotype and the D allele are associated with hypertension and type 2 diabetes in Egyptian patients (Tab. 5, Fig. 1, Ref. 32). |
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| Keywords: angiotensin converting enzyme, polymorphism, type 2 diabetes, hypertension | ||
| Published online: 13-Jan-2012 | ||
| Year: 2012, Volume: 113, Issue: 1 | Page From: 14, Page To: 18 | |
| doi:10.4149/BLL_2012_003 |
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