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Neoplasma Vol.59, No.3, p.248-256, 2012
|Title: Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-κB signaling pathway in a human breast cancer cell line|
|Author: X. LIN, X. ZHANG, Q. WANG, J. LI, P. ZHANG, M. ZHAO, X. LI|
|Abstract: P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is the major clinical impediment to chemotherapy of breast cancers. Down-regulation of PI3K/Akt pathway has been described as related to reversal of MDR in cancer cells. Here, we investigated the reversal effect on MDR phenotype of perifosine, a new Akt inhibitor, in breast cancer cell lines. In this study, MCF-7/ADM cells and MCF-7 cells were treated with different concentrations of perifosine. Our results suggested that perifosine reversed MDR partially by downregulation of P-gp expression and inhibition of PI3K/Akt/NF-κB pathway in the MCF-7/ADM cell line. The novel Akt inhibitor perifosine may be a promising new drug due to its ability to reverse MDR in human breast cancer cells.
|Keywords: perifosine, PI3K/Akt, breast cancer, multidrug resistant gene 1, P-glycoprotein|
|Received: 03-Sep-2011||Published online: 13-Feb-2012|
|Year: 2012, Volume: 59, Issue: 3||Page From: 248, Page To: 256|