Bratislava Medical Journal Vol.113, No.2, p.59-63, 2012

Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.113, No.2, p.59-63, 2012
Title: Impaired endothelium-dependent and -independent relaxation of aorta from diabetic rats
Author: M. A. Yakubu, O. A. Sofola, I. Igbo, A. O. Oyekan

Abstract: Vascular complication in diabetes has been reported to be due to the effects of chronic high blood glucose on the vascular system. Different relaxation mechanisms exist in the vasculature and effect of chronic high glucose on vascular relaxation mechanisms is not clearly understood. We assessed the effect of streptozotocin (STZ, 70 mg/kg, for 12 wks)-induced diabetes on vascular reactivity to isoproterenol (Isop, 10-9–10-5 M), a cAMP-dependent agent, acetylcholine (ACh, 10-9–10-5 M), a stimulant of NO (nitric oxide) synthase, sodium nitroprusside (SNP, 10-10–10-5 M), NO donor, or bradykinin (BK, 10-9–10-5 M) in the rat isolated aortic ring. Isop, ACh, SNP, or BK dose-dependently relaxed phenylephrine (PE, 10-7 M) pre-constricted ring producing a maximum relaxation of 82 % for Isop (10-5 M), 85 % for ACh (10-5 M), 100 % for SNP (10-6 M), and 30 % for BK (10-5 M) respectively. STZ attenuated Isop, ACh, and BK-induced relaxation by 45 % (n=7, pn (Fig. 5, Ref. 24). Full Text in PDF www.elis.sk.

Keywords: streptozotocin, endothelium, nitric oxide, ACh bradykinin, isoproterenol relaxation
	Published online: 20-Feb-2012
Year: 2012, Volume: 113, Issue: 2	Page From: 59, Page To: 63
doi:10.4149/BLL_2012_014
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