Home Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.2, p.92-94, 2012

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

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Bratislava Medical Journal Vol.113, No.2, p.92-94, 2012

Title: Iron accumulation in human spleen in autoimmune thrombocytopenia and hereditary spherocytosis
Author: C. Biro, M. Kopani, A. Kopaniova, I. Zitnanova, O. El-Hassoun, P. Minoo , L. Kolenova, V. Sisovsky, M. Caplovicova, S. Stvrtina, P. Galfiova, L. Guller, J. Jakubovsky

Abstract: Background: Although the iron is an essential element for the physiological functions of cells, tissues and organs, it is also an important inductor of reactive oxygen species (ROS).
Material and methods: Three groups of human spleen with autoimmune thrombocytopenia (AITP), hereditary spherocytosis (HS) and reference samples stained by haematoxylin and eosin, Perls’ reaction for nonheme Fe(III) iron and Alcian blue for glycoconjugates detection were studied.
Results: Positive Perls’ reaction in both AITP and HS groups was seen. Higher positivity in the HS than in AITP group was observed. HS group showed a higher amount of acidic glycoconjugates deposits than AITP group. Iron overload in HS and AITP leads to overproduction of ROS.
Conclusion: We suggest that acidic glycoconjugates deposits are involved in antioxidant defence by elimination and restriction of iron as a ROS inducer (Fig. 4, Ref. 19).

Keywords: spleen, autoimmune thrombocytopenia, hereditary spherocytosis, iron, reactive oxygen species.
Published online: 20-Feb-2012
Year: 2012, Volume: 113, Issue: 2 Page From: 92, Page To: 94

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