General Physiology and Biophysics Vol.31, No.1, p.85

General Physiology and Biophysics Vol.31, No.1, p.85–91, 2012

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.31, No.1, p.85–91, 2012
Title: Alleviation of genotoxic effects of cyclophosphamide using encapsulation into liposomes in the absence or presence of vitamin C
Author: Amany A. Tohamy, Amira A. Abdel Azeem, Medhat W. Shafaa, Wafaa S. Mahmoud

Abstract: Cyclophosphamide (CP) is a widely used anticancer and immunosuppressant that induces oxidative stress. To ameliorate the side effects resulted from CP treatment, liposomes were tested as an efficient drug delivery system with or without vitamin C as an antioxidant. CP resulted in clastogenic and cytotoxic effects that significantly increased for the total chromosomal aberrations as well as the numerical ones in the CP group (150.8 and 6, respectively) than the control group (6.6 and 0.0) as mean values at p the highly significant amelioration results were observed in the liposomised vitamin C and CP group (40.88 nmol/min/mg protein). Our findings support the potential use of CP in a liposomal formulation doped with vitamin C to diminish the potential side effects of the agent.

Keywords: Liposomes — Cyclophosphamide — Vitamin C — Oxidative stress — Chromosomal aberrations — Micronucleus assay — Glutathione S-transferase

Year: 2012, Volume: 31, Issue: 1	Page From: 85, Page To: 91
doi:10.4149/gpb_2012_009
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