General Physiology and Biophysics Vol.31, No.1, p.113

General Physiology and Biophysics Vol.31, No.1, p.113–116, 2012

Quarterly, 80 pp. per issue
Founded: 1982
ISSN 1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.31, No.1, p.113–116, 2012
Title: Estimation of rate constants of drug binding to open channels of cardiac transient outward current
Author: Jiří Šimurda, Milena Šimurdová

Abstract: An improved approach to the evaluation of the rate constants of drugs binding to the open channel underlying the transient outward potassium current Ito is described. It is based on an analysis of a quantitative model formulated by a set of twelve differential equations. The rate constants are calculated from the time constants resulting from an approximation of the time course of apparent inactivation of the recorded Ito by two exponentials in the absence and by three exponentials in the presence of a blocking agent. The model study confirmed significantly higher accuracy in comparison with the existing electrophysiological method.

Keywords: Ito channel — Drug binding — Open state — Rate constants — Mathematical model

Year: 2012, Volume: 31, Issue: 1	Page From: 113, Page To: 116
doi:10.4149/gpb_2012_013
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