Home HOME Acta Virologica 2012 Acta Virologica Vol.56, No.1, p.49-55, 2012

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Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

Published in English

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Acta Virologica Vol.56, No.1, p.49-55, 2012

Title: Inhibition of hepatitis B virus gene expression by small interfering RNAs targeting cccDNA and X antigen
Author: Q. XIE, S. ZHANG, W. WANG, Y. M. LI, T. DU, X. L. SU, Y. Q. WEI, H. X. DENG

Abstract: To test the possible inhibition of hepatitis B virus (HBV) replication and expression by small interfering RNAs (siRNAs) targeting simultaneously covalenthy closed circular DNA (dnacccDNA) and X antigen, corresponding recombinant plasmids were transfected into HepG2.2.15 cells and the levels of cccDNA, HBXAg, HBcAg, and HBeAg were assayed at various times post transfection. As expected, the single siRNAs showed marked inhibitory effects but their combination was even more efficient. These results provide a new insight into the development of a potential anti-HBV strategy of enhancing the efficacy of individual antivirals and overcoming the high mutation rate of HBV.

Keywords: hepatitis B virus; small interfering RNA; cccDNA; X antigen
Year: 2012, Volume: 56, Issue: 1 Page From: 49, Page To: 55
doi:10.4149/av_2012_01_49
Price: 14.00 €






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