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Neoplasma Vol.59, No.4, p.398-408, 2012 |
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Title: Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16INK4a expression, and HPV status | ||
Author: J. LACO, J. NEKVINDOVA, V. NOVAKOVA, P. CELAKOVSKY, H. DOLEZALOVA, L. TUCEK, H. VOSMIKOVA, M. VOSMIK, T. NESKUDLOVA, E. CERMAKOVA, M. HACOVA, F. A. SOBANDE, A. RYSKA | ||
Abstract: The aim of this study is to evaluate the biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma, with emphasis on smoking, protein p16INK4a (p16) expression, and human papillomavirus (HPV) status. The OSCCs were more likely to recur locally and to be the cause of death (p = 0.009 in both parameters).
The HPV-negative tumors were more frequently localized in oral cavity (p < 0.000001), more frequently asociated with local, regional and locoregional recurence (p = 0.011, p = 0.019 and p = 0.030, respectively) and with tumor-related death (p = 0.003). There was no significant difference with regard to smoking history (p > 0.05).
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Keywords: squamous cell carcinoma, oral cavity, oropharynx, p16 protein, HPV, prognostic factors | ||
Published online: 10-Apr-2012 | ||
Year: 2012, Volume: 59, Issue: 4 | Page From: 398, Page To: 408 | |
doi:10.4149/neo_2012_052 |
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