Home HOME Neoplasma 2012 Neoplasma Vol.59, No.4, p.398-408, 2012

Journal info


6 times a year.
Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

Editorial Info
Abstracted and Indexed
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Neoplasma Vol.59, No.4, p.398-408, 2012

Title: Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16INK4a expression, and HPV status
Author: J. LACO, J. NEKVINDOVA, V. NOVAKOVA, P.  CELAKOVSKY, H. DOLEZALOVA, L. TUCEK, H. VOSMIKOVA, M. VOSMIK, T. NESKUDLOVA, E. CERMAKOVA, M. HACOVA, F. A. SOBANDE, A. RYSKA

Abstract:

The aim of this study is to evaluate the biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma, with emphasis on smoking, protein p16INK4a (p16) expression, and human papillomavirus (HPV) status.
The study sample consisted of 48 patients with OSCC and 44 patients with OPSCC. Half of the patients were nonsmokers and the other half were gender-, age- and tumor localization-matched smokers.
p16 expression was detected in 17/48 (35 %) OSCCs and in 36/44 (82 %) OPSCCs and HPV DNA was present in 7/48 (15 %) OSCCs and in 35/44 (80 %) OPSCCs. The sensitivity and specificity of p16 expression for HPV DNA presence were 0.74 and 0.88, respectively.
The OPSCCs were more frequently basaloid (p < 0.001) while the OSCCs were more frequently conventional (p < 0.000001).

The OSCCs were more likely to recur locally and to be the cause of death (p = 0.009 in both parameters).


The HPV-positive tumors were more frequently localized in oropharynx, were basaloid SCCs and were p16- and HPV-positive (p < 0.000001 in all 4 parameters).

The HPV-negative tumors were more frequently localized in oral cavity (p < 0.000001), more frequently asociated with local, regional and locoregional recurence (p = 0.011, p = 0.019 and p = 0.030, respectively) and with tumor-related death (p = 0.003).

There was no significant difference with regard to smoking history (p > 0.05).


The survival of patients with HPV-positive tumors was significantly longer (median 112 months; 95% CI 54 – 112 months) than that of patients with HPV-negative tumors (median 17 months; 95% CI 12 – 39 months) (p < 0.001).


The HPV status of OSCC/OPSCC is an important biological and prognostic parameter and should be examined in all cases, using PCR or immunohistochemical detection of surrogate marker p16. Smoking itself does not seem to be an important prognostic factor.



Keywords: squamous cell carcinoma, oral cavity, oropharynx, p16 protein, HPV, prognostic factors
Published online: 10-Apr-2012
Year: 2012, Volume: 59, Issue: 4 Page From: 398, Page To: 408
doi:10.4149/neo_2012_052


download file



© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.