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Neoplasma Vol.59, No.4, p.433-439, 2012 |
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Title: Vascular endothelial growth factor and soluble intercellular adhesion molecule-1 in lung adenocarcinoma with malignant pleural effusion: Correlations with patient survival and pleural effusion control | ||
Author: Q. QIAN, P. ZHAN, W. K. SUN, Y. ZHANG, Y. SONG, L. K. YU | ||
Abstract: The mechanisms by which vascular endothelial growth factor (VEGF) and soluble intercellular adhesion molecule-1 (sICAM-1) contribute to lung cancer growth have not been fully elucidated. This study aimed to assess the role of VEGF and sICAM-1 in control of pleural effusions (PE) and survival in patients with primary human lung adenocarcinoma. Statistically significant correlation was observed between PE VEGF levels and MPE control. PE VEGF≥2760 pg/ml was used as a cut-off point for failure to MPE control (odds ratio=7.06; 95% confidence interval (CI), 2.40-20.78; P<0.001). The median progression-free survival (PFS) from response assessment was 3 months. In a multivariate analysis, PE VEGF (hazard ratio [HR], 1.16; 95% CI, 1.02-1.32), serum sICAM-1 (HR, 1.90; 95% CI, 1.17-3.07) were confirmed as independent prognostic factors for PFS. |
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Keywords: vascular endothelial growth factor, soluble intercellular adhesion molecule-1, malignant pleural effusion, lung adenocarcinoma, survival | ||
Published online: 10-Apr-2012 | ||
Year: 2012, Volume: 59, Issue: 4 | Page From: 433, Page To: 439 | |
doi:10.4149/neo_2012_056 |
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