Neoplasma Vol.59, No.4, p.469-474, 2012

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Neoplasma Vol.59, No.4, p.469-474, 2012
Title: Melatonin enhanced bexarotene efficacy in experimental mammary carcinogenesis
Author: P. ORENDAS, P. KUBATKA, K. KAJO, N. STOLLAROVA, M. KASSAYOVA, B. BOJKOVA, M. PEC, V. NOSAL, T. KISKOVA, K. ZIHLAVNIKOVA, R. KARSNAKOVA

Abstract: The aim of this paper was to test lower, safe bexarotene dose administered alone and in combination with melatonin to improve its efficacy. Mammary carcinogenesis was induced by N-methyl-N-nitrosourea in female Sprague-Dawley rats, administered in two doses intraperitoneally between 42.-54. postnatal days and chemoprevention was initiated 7 days prior to first N-methyl-N-nitrosourea injection and lasted 15 weeks. Bexarotene, particularly in combination with melatonin decreased mammary tumor incidence and frequency with a shift from poorly to well differentiated carcinomas. Bexarotene alleviated glycaemia and liver/heart muscle glycogen concentration decreased as well as liver/thymus malondialdehyde increased in comparison with control group. The combination of bexarotene and melatonin is therefore beneficial in preventive-curative model of experimental mammary carcinogenesis and may be applied in oncological practice as such.

Keywords: mammary carcinogenesis, female rats, bexarotene, melatonin, prevention
	Published online: 10-Apr-2012
Year: 2012, Volume: 59, Issue: 4	Page From: 469, Page To: 474
doi:10.4149/neo_2012_060
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