Home Endocrine Regulations 2012 Endocrine Regulations Vol.46, No.2, p.61-66, 2012

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Quarterly, 50 pp. per issue 
Founded: 1967
ISSN 1210-0668
E-ISSN 1336-0329

Published in English

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Endocrine Regulations Vol.46, No.2, p.61-66, 2012

Title: Relationship between disease activity and serum levels of vitamin D and parathyroid hormone in rheumatoid arthritis
Author: J. Moghimi, A. Sadeghi, M. Malek, R. Ghorbani

Abstract: Objective. Measuring vitamin D and its regulating hormones in the serum might be an accurate method for assessment of rheumatoid arthritis (RA) activity. We tested the hypothesis that the serum levels of vitamin D and parathyroid hormone (PTH) are associated with the grade of disease activity in an unselected cohort of patients with RA.
Methods. A total of 158 patients who met the American College of Rheumatology criteria for RA were examined and categorized as the patients with the active RA (n = 87) and silent RA (n = 71). Blood samples were obtained after at least eight-hour overnight fasting and the levels of 25-OH-vitamin D and PTH were measured.
Results. The levels of the vitamin D in patients with active RA were significantly lower than in those with silent RA (49.38±38.21 versus 64.64±43.61 nmol/l; p = 0.022). The PTH serum level lower than the normal range (< 0.8 nmol/l) was statistically observed similar in the active RA group compared with another ones (10.3 % versus 4.2 %, p = 0.149). Serum levels of vitamin D and PTH were not influenced by patients’ gender and age as well as the duration of disease.
Conclusion. Serum level of vitamin D was inversely related to RA activity and this relationship might be independent of PTH secretion or activity.

Keywords: rheumatoid arthritis, vitamin D, parathormone
Year: 2012, Volume: 46, Issue: 2 Page From: 61, Page To: 66
Price: 12.00 €

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