Home General Physiology and Biophysics 2012 General Physiology and Biophysics Vol.31, No.2, p.119-130, 2012

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.31, No.2, p.119-130, 2012

Title: IP3 receptors, stress and apoptosis
Author: Lubomira Lencesova, Olga Krizanova

Abstract: Abstract. Inositol 1,4,5-trisphosphate (IP3) receptors are intracellular calcium channels that are able to release calcium from intracellular stores upon activation by IP3 and modulation by calcium. IP3 receptors are involved in variety of processes during physiological, but also in the pathophysiological states. Unraveling their regulation and function, especially under the pathological situations can result in a development of new therapeutic strategies based on the IP3 receptor´s activation and/or blocking. To the stimuli that can modulate IP3 receptors belong several stress factors (e.g. immobilization stress, oxidative stress and hypoxia) and also apoptosis. Depending on the length and strength of the stress stimulus, expression of IP3 receptors can be increased, or decreased. Therefore, in this minireview modulation of IP3 receptors by some stressors is discussed. Since it was already shown that strong hypoxia might lead to the apoptosis induction, special focus will be given to the hypoxic stress and induction of apoptosis.

Keywords: Inositol-1,4,5-trisphosphate receptors — Stress — Hypoxia — Apoptosis
Year: 2012, Volume: 31, Issue: 2 Page From: 119, Page To: 130

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