Home FOR AUTHORS General Physiology and Biophysics 2012 General Physiology and Biophysics Vol.31, No.2, p.141–151, 2012

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Quarterly, 80 pp. per issue
Founded: 1982
ISSN  1338-4325 (online)

Published in English

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General Physiology and Biophysics Vol.31, No.2, p.141–151, 2012

Title: Morphological and functional characteristics of models of experimental myocardial injury induced by isoproterenol
Author: Zuzana Nichtova, Marta Novotova, Eva Kralova, Tatiana Stankovicova

Abstract: Abstract. The animal models of myocardial injury induced by systemic β-adrenergic receptor agonist administration represent an experimental approach of persisting interest. These models were found useful especially for studies of structural and functional adaptation of myocardium during the progression of cardiac adaptive response towards maladaptive hypertrophy and insufficiency. The pathological alterations induced by isoproterenol (ISO) do not develop evenly. The ISO models may contribute effectively to understanding of pathologies in signal transduction, energetics, excitability and contractility that may contribute concomitantly to cardiac dysfunction and heart failure. In this minireview we focused on the alterations in general characteristics and heart function as well as on the morphological changes of cardiomyocytes developed during ISO administration. The morphological alterations within the cellular macro- and microdomains correspond to the electrical remodeling and contractile dysfunction of ventricular myocardium that could be used to identify pathological changes ranging from hypertrophy to failing heart.

Keywords: Isoproterenol — Heart — Electrocardiogram — Hemodynamic — Ultrastructure
Year: 2012, Volume: 31, Issue: 2 Page From: 141, Page To: 151
doi:10.4149/gpb_2012_015


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