JournalsActa Virologica Bratislava Medical Journal Ekologia - Ecology Endocrine Regulations General Physiology and Biophysics Neoplasma Ahead of print 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Studia Psychologica Psychológia a patopsych. dieťaťa Building Research Journal Metallic Materials Slovenská hudba Musicologica Slovaca
Your Cart is currently empty.
Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.
Neoplasma Vol.59, No.5, p.475-485, 2012
|Title: The clinicopathological significance of Bax and Bcl-2 protein expression with tumor infiltrating lymphocytes in ovarian carcinoma|
|Author: S. YIGIT, L. DEMIR, M. O. TARHAN, F. K. CABUK, H. ELLIDOKUZ, C. ERTEN, I. SOMALI, A. DIRICAN, F. CAKALAGAOGLU|
|Abstract: The aim of the study was to establish the prognostic and predictive value of Bax and Bcl-2 proteins in conjunction with the host immune response in primary epithelial ovarian carcinoma.
83 patients were evaluated. Immunohistochemical staining was performed using anti-Bcl-2 (Dako; clone 124) and anti-Bax (Springbio; E17994) monoclonal antibodies. Additionally, the number of lymphocytes within tumor stroma lymphocyte nests were counted.
Bcl-2 protein expression was lower in advanced stage than early stage (p= 0.005). High (H) Bax expression was associated with longer overall survival (OS) than lower (L) Bax expression (p=0.03). The OS of the (L) Bax/(L) Bcl-2 group was shorter than (H) Bax/(L) Bcl-2 group in advanced stage (p=0.05). The platinum-sensitive group had a statistically significant tendency for high Bax expression (p=0.04). Furthermore, the intensity of the lymphocyte infiltration was associated with tumor differentiation (p= 0.003).
Our data suggests that (H) Bax protein expression prolongs survival, predicts platinum sensitivity and can be used after confirmation of this hypothesis in further prospective studies. The combined evaluation of Bax and Bcl-2 protein expression may provide additional significant prognostic information. The quantity of lymphocyte infiltration could be important for prognostic outcome.
|Keywords: Bax, Bcl-2, ovarian cancer, platinum sensitivity, lymphocyte infiltrate|
|Published online: 04-Jun-2012|
|Year: 2012, Volume: 59, Issue: 5||Page From: 475, Page To: 485|