Home Neoplasma 2012 Neoplasma Vol.59, No.5, p.530-535, 2012

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.59, No.5, p.530-535, 2012

Title: Lack of association between MDM2 SNP309 and TP53 Arg72Pro polymorphisms with clinical outcomes in myelodysplastic syndrome
Author: J. A. MACHADO-NETO, F. TRAINA, P. DE MELO CAMPOS, M. F. ANDREOLI-RISSO, F. F. COSTA, S. T. OLALLA SAAD

Abstract: MDM2/p53 pathway plays an important role in the control of apoptotic and proliferation mechanisms, and alterations in this pathway have been described in myelodysplastic syndromes (MDS). We investigated the frequency of MDM2 SNP309, TP53 Arg72Pro polymorphisms in de novo MDS and the association of these polymorphisms with clinical characteristics. Our results showed that the frequencies of genotypes for MDM2 SNP309 and TP53 Arg72Pro did not differ between MDS and healthy controls and that these polymorphisms were not associated with clinical and laboratory parameters, disease progression and overall survival, suggesting that MDM2 and TP53 polymorphisms are not involved in risk for MDS, or in the clinical and laboratory characteristics of the disease.

Keywords: myelodysplastic syndromes, MDM2, TP53, p53, polymorphism
Published online: 04-Jun-2012
Year: 2012, Volume: 59, Issue: 5 Page From: 530, Page To: 535
doi:10.4149/neo_2012_068


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