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Neoplasma Vol.59, No.5, p.559-565, 2012
|Title: Lung cancer in a Czech cohort exposed to radon in dwellings – 50 years of follow-up|
|Author: L. TOMASEK|
|Abstract: The presented study reports lung cancer mortality in a cohort of 11 842 subjects exposed to high levels of radon covering the period 1961-2010. Exposure estimates were based on one year measurements of radon progeny in most houses of the study area (72%), missing values in the studied area were replaced by measurements in proxy houses (9%) and exposures outside the area (19%) were based on country radon mapping. Mean concentration of 448 Bq m-3 in the study is higher than the country mean by a factor of 5.
By 2010, a total of 293 lung cancers were observed. The risk is significantly related to cumulated exposure with ERR/100Bq m-3 0.11 (90%CI: 0.04 – 0.25). This value is consistent with the risk coefficients in other indoor studies and also with the risks observed among uranium miners. The present follow-up demonstrated that increased incidence of lung cancer depends mainly on exposure from previous 5-19 years. The relative risk of lung cancer in the present study derived from this model is 1.53 (90%CI: 1.39 – 1.69).
|Keywords: residential radon, lung cancer, cohort study|
|Published online: 04-Jun-2012|
|Year: 2012, Volume: 59, Issue: 5||Page From: 559, Page To: 565|