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Neoplasma Vol.59, No.5, p.566-573, 2012 |
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Title: The relationship of multifocality and tumor burden with various tumor characteristics and survival in early breast cancer | ||
Author: G. KELEMEN, V. FARKAS, J. DEBRAH, K. ORMANDI, A. VOROS, L. KAIZER, Z. VARGA, G. LAZAR, Z. KAHAN | ||
Abstract: The presence of multifocality and the aggregate tumor size were retrospectively analysed in a database of 1071 operated breast cancers. Around a quarter of all these cancers involved multiple foci, while a tenth of the total demonstrated more than one invasive focus. Although the multifocal cancers were smaller and more often screen-detected than the unifocal cancers, their aggregate tumor size was larger, and they more frequently displayed casting-type calcifications in the mammogram and HER2 positivity. Lobular histology favoured larger tumor burden. The invasive multifocal cancers were more commonly lymph node-positive than the other tumors. In a subgroup of 584 patients with a median follow-up time of 5 years, the larger size of the invasive tumor, the presence of LVI or lymph node involvement, HER2 positivity and triple negativity were associated with a poorer RFS and OS, while the outcome of screen-detected tumors was superior to that of non-screen-detected or interval cancers. A large tumor size, lymph node positivity and HER2 positive or triple negative phenotypes were independent determinants of a poorer survival rate. |
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Keywords: breast cancer, multifocality, prognostic factor, tumor burden | ||
Published online: 04-Jun-2012 | ||
Year: 2012, Volume: 59, Issue: 5 | Page From: 566, Page To: 573 | |
doi:10.4149/neo_2012_073 |
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