Home Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.7, p.404–408, 2012

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.113, No.7, p.404–408, 2012

Title: Uncommon leukemic case of anaplastic large cell lymphoma diagnosed through a typical chromosomal abnormality t(2;5) with a null phenotype and aberrant expression of NG2 and CD13
Author: A. Kolenova, E. Mejstrikova, K. Fidlerova, E. Fronkova, L. Plank, P. Szepe, J. Jindrova, D. Sejnova, A. Zakovicova, E. Kaiserova

Abstract: Anaplastic large cell lymphoma represents approximately 10–15 % of pediatric non-Hodgkin lymphomas. Leukemic presentation is very rare, and in particular, the null phenotype ALCL without typical anaplastic morphology together with aberrant expression of CD13 and/or CD11b represents a diagnostic challenge. We report a case of a 9 year-old boy with leukemic presentation of ALCL with the typical translocation t(2;5)(p23;q35); in this patient, the only positive antigens identified by immunophenotyping were CD13, NG2 HLA-DR, and CD38. To our knowledge, aberrant expression of NG2 has never been reported in ALCL cases (Tab. 1, Fig. 6, Ref. 20)

Keywords: anaplastic large cell lymphoma, NG2 – chondroitin sulphate proteoglycan neuron-glial antigen 2, ALK- anaplastic lymphoma kinase protein
Year: 2012, Volume: 113, Issue: 7 Page From: 404, Page To: 408

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