Home Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.7, p.412–416, 2012

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.113, No.7, p.412–416, 2012

Title: Vitamin D deficiency – a possible link between osteoporosis and metabolic syndrome
Author: K. Brazdilova, A. Dlesk, T. Koller, Z. Killinger, J. Payer

Abstract: Objectives: The aim of our study was to evaluate the relationship between bone mineral density (examined by DXA – dual energy x-ray absorptiometry), vitamin D3 levels and the signs of metabolic syndrome.
Methods: We examined 55 subjects (37 women, 18 men, age median 67.8 years) with no history of osteoporosis, suffering from metabolic syndrome (defined as abdominal obesity and more than 2 of other components – arterial hypertension, dyslipidemia and diabetes mellitus or impaired glucose tolerance, according to IDF, 2006).
Results: Osteoporosis (T-score less than – 2.5) was found in 32.7 % (15 women and 3 men) and osteopenia (T-score between – 1.5 and – 2.5) in 29 % (13 women and 3 men) of patients. We observed a negative correlation between BMI and fat percentage (examined by DXA) and vitamin D3 levels. Low concentration of vitamin D3 was found in 90 % of patients with median 19.36 ug/l (64 % measured in winter, 36 % in summer, no relationship between vitamin D3 levels and season). We also observed a negative correlation between the low concentration of vitamin D3 and presence of diabetes mellitus as a part of metabolic syndrome.
Conclusion: The link between osteoporosis and metabolic syndrome could influence the therapeutic approach in both disorders and vitamin D supplementation may play an important role in prevention of these severe conditions (Tab. 5, Fig. 1, Ref. 29).

Keywords: osteoporosis, dual energy x-ray absorptiometry, vitamin D, metabolic syndrome
Year: 2012, Volume: 113, Issue: 7 Page From: 412, Page To: 416

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