Home Neoplasma 2012 Neoplasma Vol.59, No.6, p.708-718, 2012

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

Published in English

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Neoplasma Vol.59, No.6, p.708-718, 2012

Title: Signal transduction pathways participating in homeostasis and malignant transformation of the intestinal tissue

Abstract: Intestinal homeostasis is a complex and tightly regulated process governed by a variety of signalling pathways that balance cell proliferation and differentiation. As revealed by extensive use of defined mouse models, perturbations within the signalling circuitry trigger initial expansion of premalignant cells. In this review, we attempt to summarise recent advances in the knowledge of the cellular signalling mechanisms that drive tumorigenesis in the human and mouse intestine.

Keywords: colorectal cancer, epithelium, gut, intestine, mouse models, stem cells
Published online: 01-Aug-2012
Year: 2012, Volume: 59, Issue: 6 Page From: 708, Page To: 718

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