Home Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.8, p.486–489, 2012

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Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564


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Bratislava Medical Journal Vol.113, No.8, p.486–489, 2012

Title: Serum leptin level has a positive correlation with BMI and creatinine clearance in CAPD patients
Author: S. Seirafian, A. Momeni, S. Taheri, M. Mortazavi, Z. Paknahad


Objective: In a cross sectional study, 75 patients (42 males and 33 females) on continuous ambulatory peritoneal dialysis (CAPD) were enrolled from October 2007 to February 2008. Serum levels of leptin, albumin, triglyceride, dialysis adequacy (total KT/V), renal creatinine clearance (Cr Cl), mid arm circumference and demographic findings were measured in all patients.
Results: The mean age of patients was 53±14.76. The history of hemodialysis was seen in 23 patients.

Mean serum leptin level in women and men were 27±23µg/l and 16±13µg/l, respectively. A significant correlation of serum leptin level with body mass index (BMI) (p<0.001) and renal Cr Cl (p<0.001) was found.

There was no significant correlation of serum leptin level with KT/V, duration of renal failure, serum triglycerides (TG), serum low density lipoprotein (LDL) cholesterol and mid arm circumference (p>0.05).

Conclusions: To our knowledge, this is probably the first study to report that serum leptin level has a direct positive correlation with renal Cr Cl in CAPD patients. This may explain the increase in mortality in patients with lower serum leptin levels (Tab. 2, Fig. 2, Ref. 25).

Keywords: CAPD, leptin, creatinine clearance, KT/V.
Year: 2012, Volume: 113, Issue: 8 Page From: 486, Page To: 489

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