Home General Physiology and Biophysics 2012 General Physiology and Biophysics Vol.31, No.3, p.343-350, 2012

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Founded: 1982
ISSN  1338-4325 (online)

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General Physiology and Biophysics Vol.31, No.3, p.343-350, 2012

Title: The activity of G-ROS and the predominant role of Type II reaction in the photodynamic therapy using 9-hydroxypheophorbide-α for HeLa cell lines
Author: Jin-Chul Ahn, Phil-Sang Chung

Abstract: Photodynamic therapy (PDT) is a treatment modality that destroys the tumor. It activates the photosensitizer with the light of a specific wavelength, where the light is well absorbed by the photosensitizer, thus causing a fatal injury and thereby leading to a tumor necrosis. To date, a hematoporphyrin-derived photosensitizer has been widely used. It is disadvantageous, however, in that it causes a long-term photo-toxicity and has a poor selectivity for the tumor. This had led to the development of a chlorophyll-derived photosensitizer. We conducted this study to elucidate the mechanisms by which the activity of ROS is involved in the PDT using a novel type of chlorophyll-derived photosensitizer, 9-hydroxypheophorbide-α (9-HpbD-α), for the HeLa cell lines. Besides, we also attempted to determine which reaction plays a predominant role in the synthesis of ROS, either Type I reaction or Type II one, when both reactions are involved in the synthesis of ROS during the PDT using 9-HpbD-α. Our results showed not only that the activity of ROS is involved in the PDT using 9-HpbD-α in human uterine cervical cancer cell lines but also that the mechanisms of PDT are based on Type II reaction where the singlet oxygen is involved.

Keywords: Photodynamic therapy — 9-hydroxypheophorbide-α — Reactive oxygen species
Year: 2012, Volume: 31, Issue: 3 Page From: 343, Page To: 350

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