Home Bratislava Medical Journal 2012 Bratislava Medical Journal Vol.113, No.9, p.561–564, 2012

Journal info


 


Published Monthly, in English
Founded: 1919
ISSN 0006-9248
(E)ISSN 1336-0345

Impact factor 1.564

 

Aims and Scope
Editorial Info
Submission Guidelines

Select Journal







Webshop Cart

Your Cart is currently empty.

Info: Your browser does not accept cookies. To put products into your cart and purchase them you need to enable cookies.

Bratislava Medical Journal Vol.113, No.9, p.561–564, 2012

Title: Cu/Zn-superoxide dismutase, paraoxonase and arylesterase activities and malondialdehyde levels in patients with familial mediterranean fever
Author: K. Yildirim, H. Uzkeser, M. Keles, S. Yildirim, S. Karatay, A. Kiziltunc, M. Ugur

Abstract:

Objectives: In this study, alterations in antioxidant enzyme activities and malondialdehyde (MDA) levels in the serum samples of patients with familial Mediterranean fever (FMF), an autosomal recessive disease characterized by recurrent episodes of peritonitis, pleuritis, arthritis and fever, were investigated and compared with those of age- and sex-matched healthy controls.
Methods: Twenty-five patients with FMF undergoing colchicine therapy at doses of 1–1.5 mg and 25 age- and sex-matched healthy controls were included in the study. In the patients with FMF and control subjects, the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level were measured. Cu/Zn-superoxide dismutase (Cu/Zn-SOD), paraoxonase-1 (PON-1) and arylesterase (ARE) enzyme activities and MDA levels as a production of lipid peroxidation were evaluated using the appropriate methods.

Results: No statistically significant differences in the serum levels of ESR, CRP, Cu/Zn-SOD, MDA and PON-1 between the groups were observed (p>0.05).

Serum ARE activity was significantly decreased in the patients with FMF compared with the control subjects (p<0.01).


Conclusion: In conclusion, some abnormalities in the antioxidant defense system and lipid peroxidation may be observed in FMF patients during attack-free periods. However, further long-term studies on the subject are needed to explore altered lipid peroxidation and antioxidant defense mechanisms in patients with FMF (Tab. 1, Fig. 1, Ref. 35).



Keywords: familial Mediterranean fever, antioxidants, Cu/Zn-superoxide dismutase, paraoxonase, arylesterase, malondialdehyde.
Year: 2012, Volume: 113, Issue: 9 Page From: 561, Page To: 564
doi:10.4149/BLL_2012_126


download file



© AEPress s.r.o
Copyright notice: For any permission to reproduce, archive or otherwise use the documents in the ELiS, please contact AEP.