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Acta Virologica Vol.56, No.3, p.227-233, 2012
|Title: A mouse model of swine influenza virus H9N2 infection with acute lung injury|
|Author: WEI DONG, XIE LI-FENG, WANG CUN-LIAN, XU MING-JU, ZHANG RUI-HUA, LIU YING, XU TONG|
|Abstract: BALB/c mice inoculated intranasally with A/swine/HeBei/012/2008/ (H9N2) virus (SIV), showing acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), were observed for morbidity (lung histopathology, lung coefficient, lung wet/dry weight (W/D) ratio, arterial blood gas characteristics and inflammatory cells in bronchial alveolar lavage fluid (BALF)) and mortality. The results showed that, (1) on days 1–4 post infection (p.i.), mice appeared depressed and showed ruffled fur, reduced food intake, weight loss and hypoxemia with a decreased arterial partial oxygen pressure and an increased partial carbon dioxide pressure. (2) From day 4 p.i., mice began to die and showed pulmonary edema, hemorrhage and inflammatory cells in the alveolar exudate. The lung coefficient and lung W/D ratio significantly increased. (3) On days 3–8 p.i., inflammatory cells, especially alveolar macrophages and polymorphonuclears (PMNs) in BALF significantly increased. (4) The mortality rate reached 62.5%. This study established a successful animal model of ALI induced by infection with H9N2 SIV which may help in further investigations of the pathogenesis of human ALI/ARDS induced by H9N2 SIV infection.
|Keywords: wine influenza virus; H9N2 subtype; acute lung injury; mouse|
|Year: 2012, Volume: 56, Issue: 3||Page From: 227, Page To: 233|