Home Neoplasma 2013 Neoplasma Vol.60, No.1, p.92-100, 2013

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.60, No.1, p.92-100, 2013

Title: RNA-interference-mediated downregulation of Pin1 suppresses tumorigenicity of malignant melanoma A375 cells
Author: J. JIN, Y. ZHANG, Y. LI, H. ZHANG, H. LI, X. YUAN, X. LI, W. ZHOU, B. XU, C. ZHANG, Z. ZHANG, L. ZHU, X. CHEN

Abstract: The peptidyl-prolyl isomerase Pin1 is overexpressed in many human cancers, including melanoma. To investigate its possible role in oncogenesis of melanoma and as a therapeutic target, we suppressed Pin1 expression in the human melanoma cell line A375 by microRNA (miRNA) interference technology. Two stable clones with suppressed Pin1 were established by stable transfection of miRNA plasmid targeting Pin1 into A375 cells. Both clones showed reduced proliferation and invasion in vitro and suppressed tumorigenic potential in athymic mice. Furthermore, Pin1 inhibition also resulted in decreased phosphorylation of Akt and repressed expression of C-Jun N-terminal kinase and pro-matrix metalloproteinase 2, which were associated closely with the development of melanoma. These findings indicate that Pin1 plays an important role in the tumorigenesis of melanoma and might serve as a promising therapeutic target.

Keywords: malignant melanoma; A375; Pin1; RNA interference; cancer therapy
Year: 2013, Volume: 60, Issue: 1 Page From: 92, Page To: 100
doi:10.4149/neo_2013_013
Price: 18.90 €






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